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Induction of photochemical auto-reduction of cytochrome-c oxidase by an organic peroxide
Citation key ISI:000088738000011
Author Matysik, J and Hildebrandt, P and Ludwig, B
Pages 125-130
Year 2000
ISSN 0005-2728
Address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Journal Biochim. Biophys. Acta
Volume 1459
Number 1
Month JUL 20
Publisher ELSEVIER SCIENCE BV
Abstract Cytochrome-e oxidase aa(3) (CcO) from Paracoccus denitrificans interacts with tertiary butyl hydroperoxide (t-Bu-O-O-H, TBHP) by forming an adduct as indicated by an absorption shift at 408/432 nm and the induction of photochemical auto-reduction. The adduct was stable at room temperature for several days even under aerobic conditions. Upon irradiation (413 nm) of the adduct, a photoproduct, similar to the oxygenated mixed valence species (607 nm form), was formed, as indicated by the 418/442 and 607 nm signals in the absorption-difference spectrum. It is concluded that the adduct formation changes the photochemical properties of heme a(3). A molecular model for the binding mechanism of TBHP to CcO and for the photochemistry of heme a(3)-TBHP adduct is proposed. (C) 2000 Elsevier Science B.V. All rights reserved.
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